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Advanced ChemTech dota-ccmsh(arg 11
Dota Ccmsh(arg 11, supplied by Advanced ChemTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dota-ccmsh(arg+11/rvd+lys++arg+11++ccmsh/pmc02330268-62-1-16
Average 90 stars, based on 1 article reviews
dota-ccmsh(arg 11 - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Ga-68 labeled DOTA-rhenium cyclized α-MSH analog for imaging of malignant melanoma
Article Snippet: Briefly, DOTA-CCMSH(Arg 11 ) was synthesized using standard Fmoc/HBTU chemistry on an amide resin with an Advanced ChemTech Omega 396 multiple peptide synthesizer (Advanced ChemTech, Louisville, KY).

Article Title: Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH.
Article Snippet: Early detection of melanoma is essential, since a patient’s prognosis with metastatic melanoma is poor.. Previous studies showed that 111In-DOTA-ReCCMSH(Arg11), a cyclic analogue of R-melanocyte stimulating hormone (R-MSH), exhibited high tumor concentration and rapid clearance from nontarget tissue.. The goal of this current study was to label DOTA-ReCCMSH(Arg11) with â+-emitting radionuclides, to determine if the high sensitivity of positron emission tomography (PET) imaging would aid in the detection of malignant melanoma.



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A schematic structure of the rhenium-cyclized peptide, <t>203Pb-DOTA-Re(Arg11)CCMSH.</t>
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A schematic structure of the rhenium-cyclized peptide, <t>203Pb-DOTA-Re(Arg11)CCMSH.</t>
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A schematic structure of the rhenium-cyclized peptide, <t>203Pb-DOTA-Re(Arg11)CCMSH.</t>
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Image Search Results


A schematic structure of the rhenium-cyclized peptide, 203Pb-DOTA-Re(Arg11)CCMSH.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Article Title: Lead-203-Labeled Alpha-Melanocyte Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection

doi: 10.2967/jnumed.107.048553

Figure Lengend Snippet: A schematic structure of the rhenium-cyclized peptide, 203Pb-DOTA-Re(Arg11)CCMSH.

Article Snippet: Chemicals and Reagents DOTA-Re(Arg 11 )CCMSH was purchased from Bachem Inc. (King of Prussian, PA).

Techniques:

Cellular internalization (A) and efflux (B) of 203Pb-DOTA-Re(Arg11)CCMSH in B16/F1 murine melanoma cells at 25°C. Total bound radioactivity (◆), internalized activity (■), cell membrane activity (▲) and cell culture media activity (●) were presented as counts per minute (cpm).

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Article Title: Lead-203-Labeled Alpha-Melanocyte Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection

doi: 10.2967/jnumed.107.048553

Figure Lengend Snippet: Cellular internalization (A) and efflux (B) of 203Pb-DOTA-Re(Arg11)CCMSH in B16/F1 murine melanoma cells at 25°C. Total bound radioactivity (◆), internalized activity (■), cell membrane activity (▲) and cell culture media activity (●) were presented as counts per minute (cpm).

Article Snippet: Chemicals and Reagents DOTA-Re(Arg 11 )CCMSH was purchased from Bachem Inc. (King of Prussian, PA).

Techniques: Radioactivity, Activity Assay, Membrane, Cell Culture

Pharmacokinetics of 203  Pb-DOTA-Re(Arg  11 )CCMSH in B16/F1 murine melanoma-bearing C57 mice. The data are presented as percent injected dose/gram or as percent injected dose (Mean±SD, n = 5).

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Article Title: Lead-203-Labeled Alpha-Melanocyte Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection

doi: 10.2967/jnumed.107.048553

Figure Lengend Snippet: Pharmacokinetics of 203 Pb-DOTA-Re(Arg 11 )CCMSH in B16/F1 murine melanoma-bearing C57 mice. The data are presented as percent injected dose/gram or as percent injected dose (Mean±SD, n = 5).

Article Snippet: Chemicals and Reagents DOTA-Re(Arg 11 )CCMSH was purchased from Bachem Inc. (King of Prussian, PA).

Techniques: Drug discovery, Injection

Absorbed radiation doses per unit administered activity from 203  Pb-DOTA-Re(Arg  11 )CCMSH in B16/F1 murine melanoma-bearing C57 mice.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Article Title: Lead-203-Labeled Alpha-Melanocyte Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection

doi: 10.2967/jnumed.107.048553

Figure Lengend Snippet: Absorbed radiation doses per unit administered activity from 203 Pb-DOTA-Re(Arg 11 )CCMSH in B16/F1 murine melanoma-bearing C57 mice.

Article Snippet: Chemicals and Reagents DOTA-Re(Arg 11 )CCMSH was purchased from Bachem Inc. (King of Prussian, PA).

Techniques: Activity Assay

Whole-body (A) and transaxial (B) images with 203Pb-DOTA-Re(Arg11)CCMSH at 2 h post-injection in a B16/F1 murine melanoma-bearing C57 mouse.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Article Title: Lead-203-Labeled Alpha-Melanocyte Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection

doi: 10.2967/jnumed.107.048553

Figure Lengend Snippet: Whole-body (A) and transaxial (B) images with 203Pb-DOTA-Re(Arg11)CCMSH at 2 h post-injection in a B16/F1 murine melanoma-bearing C57 mouse.

Article Snippet: Chemicals and Reagents DOTA-Re(Arg 11 )CCMSH was purchased from Bachem Inc. (King of Prussian, PA).

Techniques: Injection